解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:RATIONALE AND OBJECTIVE:Drug-associated memories are hypothesized to underlie the high risk of relapse in addiction. Recent studies show that post-retrieval extinction training erases fear memories by reconsolidation blockade. Here, we examine the efficacy of this non-invasive procedure in rats with drug-associated mem...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2545-4
更新日期:2012-05-01 00:00:00
abstract:RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2527-6
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Delaying presentation of a drug can decrease its effectiveness as a reinforcer, but the effect of delaying punishment of drug self-administration is unknown. OBJECTIVE:This study examined whether a histamine injection could punish cocaine self-administration in a drug-drug choice, whether delaying histamine ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2501-3
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity. OBJECTIVES:Here, we decided to investigate the possible role of the group III mGlu receptor ligands, LSP1-2111, the g...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2502-2
更新日期:2012-04-01 00:00:00
abstract:RATIONAL:In recent years, evidence suggests that modafinil may be useful for certain symptom domains of schizophrenia, especially for the negative and cognitive symptoms. However, the results are not consistent. OBJECTIVE:This study was designed to investigate the effect of modafinil added to risperidone in patients w...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2513-z
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Previous research has identified a number of factors that appear to moderate the behavioural response to glucose administration. These include physiological state, dose, types of cognitive tasks used and level of cognitive demand. Another potential moderating factor is the length of the fasting interval prior...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2510-2
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a random...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2503-1
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis. OBJECTIVES:The present study investigates whether event-related potentials (ERPs) differ between occasional and heavy cannabis users after acute Δ9-tetrahydrocannabinol (THC) administration, as a result of to...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2479-x
更新日期:2012-03-01 00:00:00
abstract:RATIONALE:Noncontingent administration of amphetamine into the ventral striatum or systemic nicotine increases responses rewarded by inconsequential visual stimuli. When these drugs are contingently administered, rats learn to self-administer them. We recently found that rats self-administer the GABA(B) receptor agonis...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2450-x
更新日期:2012-03-01 00:00:00
abstract:RATIONALE:Little is known about the smoking topography characteristics of heavy cannabis users. Such measures may be able to predict cannabis use-related outcomes and could be used to validate self-reported measures of cannabis use. OBJECTIVES:The current study was conducted to measure cannabis smoking topography char...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-011-2480-4
更新日期:2012-03-01 00:00:00
abstract:RATIONALE:Drug development is a high-risk and high failure enterprise, and studies that provide an early read on the pharmacodynamic activity of novel compounds could save time and money, increasing the efficiency of the drug development process. OBJECTIVE:Preclinical and clinical experiments were designed to examine ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2456-4
更新日期:2012-03-01 00:00:00
abstract:RATIONALE:Phytocannabinoids are useful therapeutics for multiple applications including treatments of constipation, malaria, rheumatism, alleviation of intraocular pressure, emesis, anxiety and some neurological and neurodegenerative disorders. Consistent with these medicinal properties, extracted cannabinoids have rec...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2415-0
更新日期:2012-02-01 00:00:00
abstract:RATIONALE:Alteration of dopamine neurotransmission in the prefrontal cortex, especially hypofunction of dopamine D1 receptors, contributes to psychotic symptoms and cognitive deficit in schizophrenia. D1 receptors signal through the cAMP/PKA second messenger cascade, which is modulated by phosphodiesterase (PDE) enzyme...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2436-8
更新日期:2012-02-01 00:00:00
abstract:RATIONALE:Electrophysiological studies have identified a scalp potential, the late positive potential (LPP), which is modulated by the emotional intensity of observed stimuli. Previous work has shown that the LPP reflects the modulation of activity in extrastriate visual cortical structures, but little is known about t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2426-x
更新日期:2012-02-01 00:00:00
abstract:RATIONALE:The antidepressant nortriptyline is a second-line pharmacotherapy for smoking cessation. Given that there is limited preclinical data available on the effects of nortriptyline on responses to nicotine, the present study sought to evaluate its effects on the reinforcing, discriminative stimulus (DS) and aversi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2413-2
更新日期:2012-02-01 00:00:00
abstract:RATIONALE:Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented. OBJECTIVES:This study aims to s...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-011-2560-5
更新日期:2012-01-01 00:00:00
abstract:RATIONALE:Drug addiction is a chronically relapsing disorder characterised by compulsive drug use and loss of control over drug intake. Although several theories propose impulsivity as a key component of addiction, the precise nature of this relationship remains unclear. OBJECTIVES:This study aims to investigate the s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2558-z
更新日期:2012-01-01 00:00:00
abstract:RATIONAL:Prefrontal cortex (PFC) and dorsal striatum are part of the neural circuit critical for executive attention. The relationship between 5-HT and aspects of attention and executive control is complex depending on experimental conditions and the level of activation of different 5-HT receptors within the nuclei of ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2581-0
更新日期:2012-01-01 00:00:00
abstract:RATIONALE:Acute nicotine abstinence is associated with disruption of executive function and reward processes; however, the neurobiological basis of these effects has not been fully elucidated. METHODS:The effects of nicotine abstinence on brain function during reward-based probabilistic decision making were preliminar...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2404-3
更新日期:2012-01-01 00:00:00
abstract:RATIONALE:Although the effects of D: -cycloserine (DCS) and valproic acid (VPA) on the facilitation of the extinction of fear-conditioned memory have been elucidated in animals, these effects have not been clearly confirmed in humans. OBJECTIVE:This study aimed to determine the effect of DCS (100 mg) and VPA (400 mg) ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2353-x
更新日期:2011-12-01 00:00:00
abstract:RATIONALE:Trichotillomania is characterized by repetitive pulling causing noticeable hair loss. Pharmacological treatment data for trichotillomania are limited. OBJECTIVE:Dronabinol appears to reduce the exocitotoxic damage caused by glutamate release in the striatum and offers promise in reducing compulsive behavior....
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-011-2347-8
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Emerging data indicate the neuromodulator adenosine may play a role in the therapeutics of schizophrenia. Adenosine A(2A) receptor stimulation exerts a functional antagonism at postsynaptic D(2) receptors. Data from animal models relevant to schizophrenia support a therapeutic effect of modulating adenosiner...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2315-3
更新日期:2011-11-01 00:00:00
abstract:RATIONALE:Individual differences in the rate of nicotine metabolism (RNM) could be related to dependence and success in stopping smoking. A range of studies have examined RNM measured by the ratio of trans-3'-hydroxycotinine and cotinine in body fluids (the ratio). A systematic review of this literature is needed to dr...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-011-2341-1
更新日期:2011-11-01 00:00:00
abstract:RATIONALE:Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically. OBJECTIVES:The aims of the present study were to evaluate (1) responses to a psychological stressor, (2) r...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2376-3
更新日期:2011-11-01 00:00:00
abstract:RATIONALE:Relapse to smoking is often precipitated by stress, yet little is known about the effects of nicotine withdrawal on responses to acute stress, or whether nicotine replacement reverses withdrawal-induced changes in stress response. OBJECTIVES:The aim of the present study is to use an effective social stressor...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-010-2150-y
更新日期:2011-11-01 00:00:00
abstract:RATIONALE:The synthetic progestin medroxyprogesterone acetate (MPA), widely used in hormone therapy (HT) and as the contraceptive Depo Provera, is implicated in detrimental cognitive effects in women. Recent evidence in aged ovariectomized (Ovx) rodents shows that short-term MPA treatment impairs cognition and alters t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2322-4
更新日期:2011-11-01 00:00:00
abstract:RATIONALE:Fluoxetine (Prozac®) is the most frequently prescribed drug to battle depression in pregnant women, but its safety in the unborn child has not yet been established. Fluoxetine, a selective serotonin reuptake inhibitor, crosses the placenta, leading to increased extracellular serotonin levels and potentially n...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2299-z
更新日期:2011-10-01 00:00:00
abstract:RATIONALE:Sensory and sensorimotor gating deficits are observed in schizophrenia. GABA(B) receptor deficiency is also detected in the hippocampus of schizophrenic patients. OBJECTIVES:The present study tested the hypothesis that GABA(B) receptors in the hippocampus contribute to paired-pulse gating of hippocampal audi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2274-8
更新日期:2011-09-01 00:00:00
abstract:RATIONALE:Animal studies indicate that dopamine pathways in the ventral striatum code for the motivational salience of both rewarding and aversive stimuli, but evidence for this mechanism in humans is less established. We have developed a functional magnetic resonance imaging (fMRI) model which permits examination of t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2278-4
更新日期:2011-09-01 00:00:00
abstract:RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2282-8
更新日期:2011-09-01 00:00:00
abstract:RATIONALE:Partial dopamine receptor agonists have been proposed as candidate pharmacotherapies for cocaine dependence. OBJECTIVE:This 42-day, within-subject, human laboratory study assessed how maintenance on aripiprazole, a partial D(2) receptor agonist, influenced smoked cocaine self-administration, cardiovascular m...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-011-2231-6
更新日期:2011-08-01 00:00:00
abstract:RATIONALE:Repeated treatment with morphine has been shown to sensitize rats to its stimulant effects on motor activity and mesolimbic dopamine (DA) transmission. OBJECTIVES:The aim of this study is to investigate if morphine sensitization is associated to changes in the behavioral reactions to appetitive and aversive ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2220-9
更新日期:2011-08-01 00:00:00
abstract:RATIONALE:Treatment of the most widely abused drugs, nicotine and alcohol, is hampered by high rates of relapse. Varenicline tartrate, an α4β2 nicotinic receptor partial agonist, is currently prescribed as a smoking cessation aid. However, there is emerging evidence that it may also modulate alcohol seeking and cogniti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2213-8
更新日期:2011-07-01 00:00:00
abstract:RATIONALE:The high prevalence of smoking and low cessation rates among individuals with schizophrenia and similar conditions are not well understood. Behavioral economics has been extensively applied to studying addictive behavior and may contribute to understanding smoking in this subpopulation. OBJECTIVES:This study...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2185-8
更新日期:2011-07-01 00:00:00
abstract:RATIONALE:It has been reported that in panic disorder (PD), tryptophan depletion enhances the vulnerability to experimentally induced panic, while the administration of serotonin precursors blunts the response to challenges. OBJECTIVES:Using a high-dose carbon dioxide (CO(2)) challenge, we aimed to investigate the eff...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2177-8
更新日期:2011-06-01 00:00:00
abstract:RATIONALE:Naturally low prepulse inhibition (PPI) in DBA/2 mice is increased by marketed antipsychotics and compounds acting at novel targets relevant to schizophrenia. Whether other mouse strains with naturally low PPI respond similarly and could be translational models of schizophrenia is unknown. OBJECTIVE:Baseline...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2196-5
更新日期:2011-06-01 00:00:00
abstract:RATIONALE:Neuroanatomical evidence suggests that GABAergic deficits and progressive cortical atrophy occur with schizophrenia. OBJECTIVE:To evaluate the hypothesis that neurodevelopmental deficits affect neurodegeneration occurring with schizophrenia, this study examined a novel animal model for schizophrenia-related ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2269-5
更新日期:2011-06-01 00:00:00
abstract:RATIONALE:In patients, ketamine is a fast-acting antidepressant that can induce long-lasting symptom relief. Similar rapid effects have been reported in rodents, but reports of lasting effects are limited. OBJECTIVES:We sought to extend past findings by examining dose-response curves that overlap with the individual d...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2169-8
更新日期:2011-06-01 00:00:00
abstract:RATIONALE:Arcaine is a competitive antagonist of the polyamine binding site at the N-methyl-D-aspartic acid receptor which induces state-dependent recall. However, no study has addressed the involvement of other neurotransmitter/neuromodulators in arcaine-induced state dependency. OBJECTIVES:The current study investig...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2215-6
更新日期:2011-06-01 00:00:00
abstract:RATIONALE:Glucocorticoids have been shown to affect declarative memory, an explicit form of memory for facts and events operated by medial temporal lobe structures. Recent neuroimaging data suggest that the medial temporal lobe (including the hippocampus) is also active in implicit sequence learning. OBJECTIVES:The ai...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-010-2112-4
更新日期:2011-05-01 00:00:00